Diagnosis

Western Equine Encephalitis (CSF)

Choose a preferred language


Does this test have other names?

No.


What is this test?

This test looks for the virus that causes Western equine encephalitis. This is a disease that is spread through bites from infected mosquitoes. Babies and young children who are infected are more likely to get inflammation of the brain (encephalitis). Adults are less likely to have this problem. Horses can also become infected.

This test uses a sample of cerebrospinal fluid. The fluid surrounds the brain and spinal cord.


Why do I need this test?

You may need this test to find out if you are infected with the virus that causes Western equine encephalitis. Symptoms can show up quickly. They may include:

  • Fever.

  • Drowsiness.

  • Tiredness (fatigue).

  • Dizziness.

  • Weakness.

  • Headache.

  • Backache.

  • Nausea and vomiting.

  • Neck stiffness.

  • Disorientation.

Symptoms of Western equine encephalitis in babies include fussiness, vomiting, fever, failure to eat, and seizures.


What other tests might I have along with this test?

You may also have a blood test to check for the virus.


What do my test results mean?

Test results may vary depending on your age, gender, health history, and other things. . Ask your doctor what your test results mean for you.

This test measures levels of immunoglobulin M (IgM). IgM is a type of antibody that your immune system makes against the virus. If your CSF sample contains IgM antibodies, you may have the disease.


How is this test done?

This test is done with a sample of cerebrospinal fluid. The doctor takes the sample during a spinal tap (lumbar puncture) in your lower back. During this test, you either sit up and lean forward or lie down on your side. The doctor puts a needle into your lower back. They draw out a sample of fluid through the needle.


Does this test pose any risks?

Side effects of a lumbar puncture include:

  • Discomfort while the needle is put in.

  • Headache.

  • Infection.

  • Bleeding.

  • Brain herniation. This is rare but life-threatening.


What might affect my test results?

Tell your doctor if you're taking medicine or have any other health conditions.


How do I get ready for this test?

Doctors sometimes use local anesthesia to numb the spot where the needle will be put in. This is especially true for children. Children may get upset about the procedure. So a doctor or child specialist should explain to the child what to expect.

Doctors sometimes use a CT scan to make images of the brain before this test. This is to check for high pressure in the skull. High pressure could lead to brain herniation from the procedure.

Be sure your doctor knows about all medicines, herbs, vitamins, and supplements you are taking. This includes medicines that don't need a prescription and any illicit drugs you may use.

Author: Metcalf, Eric

Online Medical Reviewer: Chad Haldeman-Englert MD

Online Medical Reviewer: Raymond Turley Jr PA-C

Online Medical Reviewer: Tara Novick BSN MSN

Date Last Reviewed: 06/30/2025

© 2000-2026 The StayWell Company, LLC. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.

Get Connected to a Care Manager

Get Connected
Related Articles
Read article
Hematology
Gram Stain

This test finds out whether you have a bacterial infection. Samples for this test may be collected from different areas of the body, such as a knee joint or the throat.

Read article
Hematology
Cortisol (Blood)

This test may help in the diagnosis of two fairly uncommon medical conditions: Cushing syndrome and Addison disease. The test also screens for other diseases that affect your pituitary and adrenal glands.

Read article
Hematology
Gamma-Glutamyl Transpeptidase

This test looks for an enzyme called gamma-glutamyl transpeptidase in your blood. The test can help find out whether you have liver damage.

Read article
Hematology
Total and Free Carnitine

This test measures the amount of a substance called carnitine in your blood. Carnitine makes it possible for your body to digest fatty acids.