Treatment

Hyperthermia for Cancer Treatment


What is hyperthermia in cancer treatment?

Hyperthermia is heat therapy. Heat has been used for hundreds of years as cancer therapy. Scientists believe that heat may help shrink tumors by damaging cells or depriving them of what they need to live. It may also make the cancer cells more sensitive to other cancer treatments like radiation and chemotherapy. Research studies are underway to determine the use and effectiveness of hyperthermia in cancer treatment. It's used at some cancer treatment centers along with chemotherapy or radiation to treat advanced cancer. It's not widely available.


How is it used?

Heat can be applied to a very small area, to an organ or limb, or to the whole body. Hyperthermia is often used with chemotherapy, radiation therapy, and other cancer treatments. These are the types of hyperthermia:

Type of hyperthermia

Treatment area

Method of application

Local hyperthermia

Treatment area includes a tumor or other small area.

  • Heat is applied from the outside with high-frequency waves aimed at the tumor.
  • Inside the body, a small area may be heated with thin, heated wire probes or an implanted microwave antennae and radiofrequency electrodes (radiofrequency ablation).

Regional hyperthermia

An organ or a limb is treated.

  • Devices that make high energy are placed over the region to be heated.
  • Some of the blood is removed, heated, and then pumped into the region to be heated. The process is called perfusion.
  • Heated chemotherapy medicine is placed in the peritoneum during surgery

Whole-body hyperthermia

The whole body is treated.

  • Warm water blankets
  • Inductive coils (like the coils in an electric blanket)
  • Thermal room or chambers


Are there any side effects?

Side effects may include skin discomfort or local pain. Hyperthermia can also cause blisters and sometimes burns. But these generally heal quickly. Local hyperthermia can cause pain at the site, infection, blood clots, burns, and damage to the muscles, skin, and nerves in the treated area. Whole-body hyperthermia can cause diarrhea, nausea, and vomiting. Improved technology, research, and treatment experience have resulted in fewer side effects. Most side effects people have are short-term and not serious. Regional hyperthermia and whole-body hyperthermia are seldom used in the modern era due to lack of data to support their use. The most common use of hyperthermia is local hyperthermia using radiofrequency ablation most often used to treat liver tumors.

Featured in

Author: Ignite Staff

Online Medical Reviewer: Anne Fetterman RN BSN

Online Medical Reviewer: Heather M Trevino BSN RNC

Online Medical Reviewer: Warren Brenn

Date Last Reviewed: 08/31/2025

© 2000-2026 The StayWell Company, LLC. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.

Get Connected to a Care Manager

Get Connected
Related Articles
Read article
Oncology
Cancer of Unknown Primary: Surgery

During surgery, your doctor removes a tumor or tumors from your body. Most of the time, your doctor tries to take out all the cancer and some of the normal tissue around it.

Read article
Oncology
Lung Cancer: Targeted Therapy

Targeted therapy uses medicines that target specific parts of cancer cells or nearby cells that would normally help the cancer grow and spread. Targeted medicines can sometimes be more helpful than standard chemotherapy (chemo) medicines.

Read article
Oncology
Radiofrequency Ablation (RFA) of Lung Tumors

This procedure uses a small needle electrode to send an electrical current to heat and kill cancer cells. The heat also closes nearby blood vessels, limiting bleeding. Read on to learn more about what to expect with this procedure.

Read article
Oncology
Kaposi Sarcoma: Treatment Choices

Read on to learn about your treatment options for Kaposi sarcoma.