WHY is this medicine prescribed?
Tezepelumab injection is used to prevent wheezing, difficulty breathing, chest tightness, and coughing caused by asthma. It is also used to treat chronic rhinosinusitis with nasal polyps (an ongoing sinus condition). Tezepelumab injection is in a class of medications called monoclonal antibodies. It works by reducing a certain type of white blood cell to help decrease swelling and irritation of the airways to allow for easier breathing.
HOW should this medicine be used?
Tezepelumab injection comes as a solution (liquid) in single-dose, prefilled syringes, prefilled dosing pens, and vials to inject subcutaneously (just under the skin) into your upper arm, thigh, or abdomen. Give once every 4 weeks. Your doctor will determine the length of your treatment based on your condition and how well you respond to the medication.
Tezepelumab may be given to you by a nurse or other healthcare provider, or you may be told to inject the medication by yourself at home using a prefilled dosing pen. If you will be injecting tezepelumab yourself, a healthcare provider will show you how to inject the medication. Carefully read the manufacturer's instructions for use that comes with the medication. Be sure to ask your pharmacist or doctor if you have any questions about how to inject this medication.
Tezepelumab injection is not used to treat a sudden attack of asthma symptoms. Talk to your doctor about how to treat symptoms of a sudden asthma attack. If your asthma symptoms get worse or if you have asthma attacks more often, be sure to talk to your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Are there OTHER USES for this medicine?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What SPECIAL PRECAUTIONS should I follow?
Before receiving tezepelumab injection,
- tell your doctor or pharmacist if you are allergic to this drug, any part of this drug, or any other
drugs, foods or substances. Tell your doctor or pharmacist about the allergy and what
symptoms you had. - tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, you are taking or plan to take.
- tell your doctor if you have a parasitic (worm) infection.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving tezepelumab, call your doctor.
- do not have any vaccinations without talking to your doctor.
What SPECIAL DIETARY instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do IF I FORGET to take a dose?
If you forget to inject your dose, inject the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not inject a double dose to make up for a missed one.
If you miss an appointment to receive a dose of tezepelumab injection, call your doctor to reschedule the appointment.
What SIDE EFFECTS can this medicine cause?
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
- rash; hives; difficulty breathing; swelling of the eyes, face, lips, tongue, or throat; fainting, dizziness, feeling lightheaded;
- red, itchy, swollen or inflamed eyes
Tezepelumab may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, away from light, closed, and out of reach of children. Store tezepelumab injection in the refrigerator. Do not freeze or shake tezepelumab, and do not expose the medication to high temperatures. If a refrigerator is not available, you can store tezepelumab injection at room temperature, away from heat and light, for up to 30 days. Tezepelumab injection should not be put back into the refrigerator after it has been stored at room temperature.
Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location – one that is up and away and out of their sight and reach. https://www.upandaway.org
Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website https://goo.gl/c4Rm4p for more information.
What OTHER INFORMATION should I know?
Keep all appointments with your doctor.
Ask your pharmacist any questions you have about tezepelumab injection.
Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.
Brand Name(s):
- Tezspire®
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS® Patient Medication Information™. © Copyright, 2024. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: December 15, 2025.
